Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634784 | 0.81 | TCF4 (0.41) | DAOCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL7087792 | 0.72 | CES2 (0.53) | DAOCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL8093355 | 0.72 | CYP1A2 (0.42) | DAOCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL5788690 | 0.71 | LTA4H (0.49) | CYP1A2CYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8094065 | 0.70 | LMNA (0.40) | CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL8094061 | 0.70 | LMNA (0.40) | CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10968608 | 0.68 | DAO (0.36) | DAOCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL6643910 | 0.64 | DAO (0.47) | DAOCYP2C19KMT2ASMN1; SMN2POLB | |
| SCHEMBL10274823 | 0.64 | DAO (0.61) | DAOKDRSMN1; SMN2 | |
| SCHEMBL3047680 | 0.64 | DAO (0.61) | DAOKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |