Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099890 | 0.90 | GHSR (0.39) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8090988 | 0.85 | MTOR (0.44) | PIK3CDALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL8097177 | 0.84 | PIK3CD (0.39) | PIK3CDRAB9ACA12CA1CA2 | |
| SCHEMBL8083982 | 0.82 | PIK3CD (0.34) | PIK3CDALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL8096884 | 0.82 | KDM4E (0.39) | PIK3CDRAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL8091937 | 0.81 | CA12 (0.39) | PIK3CDRAB9ACA12CA1CA2 | |
| SCHEMBL8089937 | 0.81 | KIF11 (0.39) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL8091600 | 0.80 | PIK3CA (0.40) | PIK3CDPIK3CA | |
| SCHEMBL8097581 | 0.80 | MAPT (0.38) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8089094 | 0.79 | PIK3CD (0.43) | PIK3CDCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |