Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091600 | 0.82 | PIK3CA (0.40) | PIK3CDPIK3CA | |
| SCHEMBL8096884 | 0.81 | KDM4E (0.39) | PIK3CDPIK3CA | |
| SCHEMBL8092177 | 0.81 | FPR2 (0.47) | FPR2MAPK1PIK3CDROCK2ROCK1 | |
| SCHEMBL8090988 | 0.80 | MTOR (0.44) | PIK3CDPIK3CA | |
| SCHEMBL8092577 | 0.80 | FPR2 (0.46) | FPR2MAPK1 | |
| SCHEMBL8089937 | 0.79 | KIF11 (0.39) | — | |
| SCHEMBL8083982 | 0.78 | PIK3CD (0.34) | PIK3CDPIK3CA | |
| SCHEMBL8099890 | 0.78 | GHSR (0.39) | PIK3CDROCK2 | |
| SCHEMBL8215025 | 0.78 | FPR2 (0.51) | FPR2MAPK1ADORA3ADORA2AADORA1 | |
| SCHEMBL8095224 | 0.77 | PIK3CD (0.34) | MAPK1PIK3CDPIK3CAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |