Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092637 | 0.93 | KMT2A (0.42) | KMT2ACA2CA9PIK3CAMTOR | |
| SCHEMBL8083973 | 0.91 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1RAB9ACA2 | |
| SCHEMBL8090246 | 0.91 | PIK3CA (0.42) | ALDH1A1KMT2AMEN1HPGDPIK3CA | |
| SCHEMBL8099749 | 0.90 | MTOR (0.40) | KMT2APIK3CAMTORPIK3CG | |
| SCHEMBL8097712 | 0.88 | KMT2A (0.39) | KMT2AMEN1CA2CA9PIK3CA | |
| SCHEMBL8096342 | 0.88 | PIK3CA (0.41) | ALDH1A1KMT2AMEN1HPGDPIK3CA | |
| SCHEMBL8089917 | 0.88 | PIK3CA (0.39) | ALDH1A1KMT2ACA2CA9PIK3CA | |
| SCHEMBL8099632 | 0.87 | CA1 (0.42) | ALDH1A1KMT2AMEN1LMNAHPGD | |
| SCHEMBL8093151 | 0.87 | KMT2A (0.37) | ALDH1A1KMT2AMEN1LMNARAB9A | |
| SCHEMBL8097448 | 0.86 | PIK3CA (0.43) | ALDH1A1KMT2AMEN1HPGDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |