Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083973 | 0.88 | ALDH1A1 (0.43) | KMT2AMEN1PIK3CAMTORPIK3CG | |
| SCHEMBL8092637 | 0.88 | KMT2A (0.42) | KMT2APIK3CAMTORPIK3CGPKM | |
| SCHEMBL8097257 | 0.87 | ALDH1A1 (0.41) | KMT2AMEN1LMNAPIK3CAMTOR | |
| SCHEMBL8090246 | 0.86 | PIK3CA (0.42) | KMT2AMAPTMEN1HTTNPSR1 | |
| SCHEMBL8099749 | 0.85 | MTOR (0.40) | KMT2APIK3CAMTORPIK3CG | |
| SCHEMBL8097712 | 0.84 | KMT2A (0.39) | KMT2AMEN1PIK3CAMTORPIK3CG | |
| SCHEMBL8089917 | 0.84 | PIK3CA (0.39) | KMT2APIK3CAMTORPIK3CGALDH1A1 | |
| SCHEMBL8096342 | 0.82 | PIK3CA (0.41) | KMT2AMAPTMEN1HTTNPSR1 | |
| SCHEMBL8094423 | 0.82 | CA2 (0.43) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL3923616 | 0.81 | PIK3CA (0.54) | PIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |