Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090786 | 0.90 | SGK1 (0.37) | MTORF10SGK1NAMPTNR2E3 | |
| SCHEMBL8094263 | 0.88 | PIK3CA (0.40) | MTORPIK3CAPIK3CGCA12CA1 | |
| SCHEMBL8090246 | 0.87 | PIK3CA (0.42) | MTORPIK3CAPIK3CGCDK1CDK2 | |
| SCHEMBL8091790 | 0.87 | NAMPT (0.38) | MTORPIK3CAPIK3CGNAMPTPIK3CD | |
| SCHEMBL8096070 | 0.84 | MTOR (0.40) | MTORPIK3CAPIK3CGCDK1CDK2 | |
| SCHEMBL8097448 | 0.83 | PIK3CA (0.43) | MTORPIK3CAPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL8096342 | 0.83 | PIK3CA (0.41) | MTORPIK3CAPIK3CGCDK1CDK2 | |
| SCHEMBL8091073 | 0.83 | KMT2A (0.37) | MTORPIK3CAPIK3CGCDK1CDK2 | |
| SCHEMBL8094423 | 0.83 | CA2 (0.43) | MTORPIK3CAPIK3CGCA12CA1 | |
| SCHEMBL8092637 | 0.83 | KMT2A (0.42) | MTORPIK3CAPIK3CGCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |