Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | DDX3X | O00571 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098751 | 0.87 | MTOR (0.40) | NAMPTPIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8090246 | 0.85 | PIK3CA (0.42) | NAMPTPIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8096070 | 0.81 | MTOR (0.40) | NAMPTPIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL8097448 | 0.81 | PIK3CA (0.43) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8083973 | 0.81 | ALDH1A1 (0.43) | NAMPTPIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL8089917 | 0.81 | PIK3CA (0.39) | NAMPTPIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8096342 | 0.81 | PIK3CA (0.41) | NAMPTPIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL3926120 | 0.81 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL8092637 | 0.81 | KMT2A (0.42) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8219083 | 0.80 | NAMPT (0.40) | NAMPTPIK3CAMTORPIK3CGDDX3X |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |