Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 5/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 5/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098751 | 0.90 | MTOR (0.40) | SGK1MTORNR2E3F10ALDH1A1 | |
| SCHEMBL8091143 | 0.89 | KIF11 (0.36) | SGK1F10MEN1KMT2AALDH1A1 | |
| SCHEMBL8083416 | 0.89 | PIK3R1 (0.39) | SGK1F10MEN1KMT2AALDH1A1 | |
| SCHEMBL8094263 | 0.87 | PIK3CA (0.40) | SGK1MTORNAMPT | |
| SCHEMBL8090244 | 0.86 | MTOR (0.34) | MTORKDREPHB4TEK | |
| SCHEMBL8091293 | 0.86 | MAPT (0.42) | MTORMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8083654 | 0.86 | HSD11B1 (0.33) | SGK1MTORKDREPHB4TEK | |
| SCHEMBL8096681 | 0.83 | ATR (0.40) | MTORMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8104712 | 0.82 | IDO1 (0.40) | SGK1MTORMEN1KMT2AALDH1A1 | |
| SCHEMBL8082685 | 0.82 | IDO1 (0.40) | SGK1MTORALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |