Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.58 |
| ▸ | HTR7 | P34969 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | DRD5 | P21918 | 3/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103525 | 0.88 | HTR2A (0.65) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL8103814 | 0.87 | HTR1A (0.63) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL8102136 | 0.86 | CTSS (0.67) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL8108057 | 0.85 | HTR1A (0.61) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL8103915 | 0.82 | CTSS (0.60) | DRD2HTR7HTR2AHTR1AHTR6 | |
| Hydrochloric Acid SCHEMBL8557013 | 0.81 | DRD2 (0.62) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL8103442 | 0.81 | HTR2A (0.68) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL8103844 | 0.79 | HTR2A (0.65) | DRD2HTR7HTR2AHTR1AHTR6 | |
| Hydrochloric Acid SCHEMBL8554434 | 0.78 | HTR7 (0.64) | DRD2HTR7HTR2AHTR1AHTR6 | |
| Hydrochloric Acid SCHEMBL8402882 | 0.77 | DRD2 (0.57) | DRD2HTR7HTR2AHTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |