Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.44 |
| ▸ | DRD1 | P21728 | 4/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | HRH2 | P25021 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107912 | 0.96 | CYP2D6 (0.42) | CYP2D6LMNAMAPTCYP1A2HTR1A | |
| SCHEMBL8101555 | 0.88 | CYP2D6 (0.54) | CYP2D6LMNAMAPTCYP1A2HTR1A | |
| SCHEMBL8093557 | 0.84 | CYP2D6 (0.51) | CYP2D6LMNAMAPTCYP1A2HTR1A | |
| SCHEMBL8101320 | 0.80 | CYP2D6 (0.40) | CYP2D6LMNAMAPTCYP1A2HTR1A | |
| SCHEMBL8101312 | 0.76 | HTR1A (0.39) | CYP2D6LMNAMAPTCYP1A2HTR1A | |
| SCHEMBL8101881 | 0.72 | ALDH1A1 (0.43) | CYP2D6MAPTCYP1A2CHRM2ADRA2B | |
| SCHEMBL8103434 | 0.70 | ADRA2A (0.34) | LMNAADRA2BADRA2CADRA2AADORA3 | |
| SCHEMBL8107632 | 0.70 | ADRA2A (0.36) | CYP2D6MAPTCYP1A2CHRM2ADRA2B | |
| SCHEMBL7468232 | 0.69 | ADRA2A (0.33) | LMNAADRA2BADRA2CCHRM3SLC6A2 | |
| Prothipendyl SCHEMBL29393787 | 0.69 | CYP2D6 (0.72) | CYP2D6LMNAMAPTCYP1A2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |