Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101367 | 0.89 | ALDH1A1 (0.37) | ALDH1A1TP53MAPK1ALDH2ALDH3A1 | |
| SCHEMBL8101881 | 0.87 | ALDH1A1 (0.43) | ADRA2AADRA2BADRA2CALDH1A1TP53 | |
| SCHEMBL8103457 | 0.82 | ALDH1A1 (0.44) | ADRA2AADRA2BADRA2CALDH1A1TP53 | |
| SCHEMBL8101315 | 0.81 | ALDH1A1 (0.38) | ADRA2AADRA2BADRA2CALDH1A1TP53 | |
| SCHEMBL8101460 | 0.79 | PKM (0.36) | ALDH1A1TP53MAPK1ALDH2ALDH3A1 | |
| SCHEMBL8103437 | 0.76 | ALDH1A1 (0.39) | ADRA2AADRA2BADRA2CALDH1A1TP53 | |
| SCHEMBL4316094 | 0.76 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL8107425 | 0.76 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL8107634 | 0.74 | PKM (0.37) | ALDH1A1TP53MAPK1KMT2AMEN1 | |
| SCHEMBL8107544 | 0.71 | ALDH1A1 (0.33) | ADRA2AADRA2BADRA2CALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |