Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468232 | 0.95 | ADRA2A (0.33) | ADRA2AADRA2BADRA2CLMNANOS3 | |
| SCHEMBL8101449 | 0.83 | MYC (0.40) | ADRA2AADRA2BADRA2CLMNANOS3 | |
| SCHEMBL8103219 | 0.77 | ADORA3 (0.39) | ADRA2AADRA2BADRA2CLMNANOS3 | |
| SCHEMBL8109276 | 0.76 | ALDH1A1 (0.46) | LMNASMN1; SMN2ADORA3ADORA2AADORA1 | |
| SCHEMBL8103233 | 0.73 | KDM4E (0.40) | LMNASMN1; SMN2BRD4 | |
| SCHEMBL8107912 | 0.71 | CYP2D6 (0.42) | ADRA2AADRA2BADRA2CLMNASMN1; SMN2 | |
| SCHEMBL8101322 | 0.71 | — | — | |
| SCHEMBL8103445 | 0.70 | CYP2D6 (0.44) | ADRA2AADRA2BADRA2CLMNASMN1; SMN2 | |
| SCHEMBL8103439 | 0.69 | KDM4E (0.40) | LMNASMN1; SMN2BRD4 | |
| SCHEMBL8107564 | 0.69 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CLMNABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |