Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096944 | 0.94 | SMN1; SMN2 (0.39) | P4HTMPTGS2EGFRKMT2ASMN1; SMN2 | |
| SCHEMBL8768258 | 0.91 | CA1 (0.39) | P4HTMKDM4EALDH1A1PTGS2EGFR | |
| SCHEMBL8874117 | 0.88 | P4HTM (0.38) | P4HTMKDM4EALDH1A1PTGS2EGFR | |
| SCHEMBL8104048 | 0.87 | PTGS2 (0.44) | P4HTMPTGS2EGFRNPC1RAB9A | |
| SCHEMBL8099449 | 0.84 | LMNA (0.37) | PTGS2EGFRSMN1; SMN2SCN9A | |
| SCHEMBL8767162 | 0.84 | LMNA (0.40) | P4HTMPTGS2EGFRLIMK1SMN1; SMN2 | |
| SCHEMBL8875242 | 0.84 | LIMK1 (0.39) | P4HTMKDM4EALDH1A1PTGS2EGFR | |
| SCHEMBL8106135 | 0.84 | LMNA (0.40) | P4HTMPTGS2EGFRLIMK1NPC1 | |
| SCHEMBL8097664 | 0.83 | ABL1 (0.37) | P4HTMPTGS2EGFRSMN1; SMN2SCN9A | |
| SCHEMBL8768279 | 0.83 | LMNA (0.42) | ALDH1A1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673932-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 2000-06-07 | — | — | EP | disclosed |
| EP-0673932-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |