Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 4/20 | 0.61 |
| ▸ | FAAH | O00519 | 4/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19149704 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL547835 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL12040622 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL5681573 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL6213668 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL24340640 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL13498521 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL2632727 | 1.00 | MAPT (0.71) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| SCHEMBL1105483 | 0.98 | ALDH1A1 (0.73) | MAPTRXFP1ALDH1A1ALOX5HDAC1 | |
| Formaldehyde SCHEMBL6456543 | 0.94 | ALDH1A1 (0.68) | MAPTRXFP1ALDH1A1ALOX5HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170196854-A1 | USE OF ANTHELMINTIC AGENTS AGAINST DIROFILARIA IMMITIS | INTERVET INC. (US) | 2017-07-13 | — | — | US | disclosed |
| US-9096524-B2 | Anthelmintic agents and their use | INTERVET INTERNATIONAL B.V. (NL) | 2015-08-04 | — | — | US | disclosed |
| US-20130164325-A1 | CERAMIDE-LIKE GLYCOLIPID-ASSOCIATED BACTERIAL VACCINES AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130164325-A1 | CERAMIDE-LIKE GLYCOLIPID-ASSOCIATED BACTERIAL VACCINES AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-06-27 | — | — | US | disclosed |
| US-20110319393-A1 | ANTHELMINTIC AGENTS AND THEIR USE | INTERVET INTERNATIONAL B.V. (NL) | 2011-12-29 | — | — | US | disclosed |
| EP-1660507-B9 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-03-24 | — | — | EP | disclosed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |
| US-4131745-A | ANTIDEPRESSANT | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1978-12-26 | — | — | US | disclosed |
| US-4125541-A | Aryl substituted ketones | STERLING DRUG INC. (US) | 1978-11-14 | — | — | US | disclosed |
| US-4125714-A | Aryl substituted cycloalkanones | STERLING DRUG INC. (US) | 1978-11-14 | — | — | US | disclosed |
| US-4118511-A | Aryloxy aminobutanols for alleviating symptoms of depression | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1978-10-03 | — | — | US | disclosed |
| US-4071552-A | Aryloxy aminobutanols, their preparation and use thereof | AYERST MCKENNA AND HARRISON LTD. (CA) | 1978-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319393-A1 | ANTHELMINTIC AGENTS AND THEIR USE | ACHE, ABCB11, MPO | MAPT 1648/4885RXFP1 4117/4885ALDH1A1 864/4885 |
| US-20170196854-A1 | USE OF ANTHELMINTIC AGENTS AGAINST DIROFILARIA IMMITIS | MPO, DHODH, DHX35 | MAPT 2413/4885RXFP1 3756/4885ALDH1A1 1001/4885 |
| US-20130164325-A1 | CERAMIDE-LIKE GLYCOLIPID-ASSOCIATED BACTERIAL VACCINES AND USES THEREOF | SGMS1, CERT1, SGMS2 | MAPT 2071/4885RXFP1 3556/4885ALDH1A1 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.