Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 17/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 15/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018645 | 0.81 | OPRL1 (0.49) | OPRL1 | |
| SCHEMBL13267701 | 0.81 | OPRM1 (0.33) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL3026182 | 0.73 | OPRL1 (0.48) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL10639902 | 0.67 | OPRL1 (0.61) | OPRL1OPRM1OPRK1OPRD1CYP2D6 | |
| SCHEMBL8108528 | 0.66 | — | — | |
| SCHEMBL4870591 | 0.65 | OPRM1 (0.55) | OPRL1OPRM1OPRK1OPRD1CYP2D6 | |
| SCHEMBL19343390 | 0.65 | OPRL1 (0.82) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL10639858 | 0.65 | OPRL1 (0.63) | OPRL1OPRM1OPRK1OPRD1CYP2D6 | |
| SCHEMBL3015736 | 0.65 | OPRL1 (0.49) | OPRL1 | |
| Bromide SCHEMBL11481839 | 0.64 | KCNA3 (0.45) | OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170903-B1 | SPIRO[PIPERIDINE-4,4' -THIENO[3, 2-C]PYRAN]DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE SIGMA RECEPTOR FOR THE TREATMENT OF PSYCHOSIS | ESTEVE LABOR DR (ES) | 2012-09-05 | — | — | EP | disclosed |
| US-20100190813-A1 | SPIRO [PIPERIDINE-4- 4' -THIENO [3,2-C] PYRAN] DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE SIGMA RECEPTOR FOR THE TREATMENT OF PSYCHOSIS | OBERDORF CHRISTOPH | 2010-07-29 | — | — | US | disclosed |
| EP-2020414-A1 | spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis | Laboratorios del Dr. Esteve S.A. (ES) | 2009-02-04 | — | — | EP | disclosed |
| WO-2008155132-A1 | SPIRO [PIPERIDINE-4, 4' -THIENO [3, 2-C] PYRAN] DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE SIGMA RECEPTOR FOR THE TREATMENT OF PSYCHOSIS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190813-A1 | SPIRO [PIPERIDINE-4- 4' -THIENO [3,2-C] PYRAN] DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE SIGMA RECEPTOR FOR THE TREATMENT OF PSYCHOSIS | SIGMAR1, OPRD1, OPRK1 | OPRL1 6/4885OPRM1 12/4885OPRK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.