Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.51 |
| ▸ | CA12 | O43570 | 4/20 | 0.51 |
| ▸ | CA9 | Q16790 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098834 | 0.86 | PDE7A (0.64) | CA2CA12CA9CA1PDE7A | |
| SCHEMBL8104943 | 0.83 | CA2 (0.48) | CA2CA12CA9CA1PDE7A | |
| SCHEMBL8105044 | 0.80 | CA2 (0.54) | CA2CA12CA9CA1CA5A | |
| SCHEMBL22815433 | 0.78 | PDE7A (0.74) | PDE7APDE7BMAPTMAPK1KMT2A | |
| SCHEMBL8107622 | 0.77 | IDO1 (0.55) | CA2CA12CA9CA1PDE7A | |
| SCHEMBL8107806 | 0.74 | VCAM1 (0.56) | CA2CA12CA9CA1PDE7A | |
| SCHEMBL8101207 | 0.73 | PTGS2 (0.54) | CA2CA12CA9CA1SLC6A4 | |
| SCHEMBL29242001 | 0.72 | CA2 (0.68) | CA2CA12CA9CA1VCAM1 | |
| SCHEMBL4607929 | 0.72 | PDE7A (0.55) | PDE7APDE7BMAPTMAPK1KMT2A | |
| SCHEMBL27915770 | 0.71 | CA2 (0.72) | CA2CA12CA9CA1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |
| EP-0848703-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | Nycomed Austria GmbH (AT) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997003953-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1997-02-06 | — | — | WO | disclosed |