Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.59 |
| ▸ | DRD2 | P14416 | 7/20 | 0.59 |
| ▸ | DRD3 | P35462 | 7/20 | 0.59 |
| ▸ | HTR2A | P28223 | 5/20 | 0.59 |
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | DRD5 | P21918 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116371 | 0.87 | SIGMAR1 (0.48) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL8776471 | 0.80 | HTR1A (0.56) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL26108581 | 0.79 | HTR1A (0.65) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL26492991 | 0.79 | HTR1A (0.65) | HTR1ADRD2DRD3HTR2ADRD1 | |
| Hydrochloric Acid SCHEMBL26108377 | 0.77 | DRD2 (0.63) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL9633099 | 0.76 | HTR1A (0.75) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL28550858 | 0.75 | SIGMAR1 (0.50) | HTR1ADRD2DRD3HTR2ADRD4 | |
| SCHEMBL28556405 | 0.75 | HRH4 (0.49) | DRD2DRD3DRD4HRH3HRH1 | |
| SCHEMBL9260064 | 0.75 | HTR1A (0.60) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL8776570 | 0.74 | DRD2 (0.56) | HTR1ADRD2DRD3HTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610140-B1 | 2-[4-(4-Azolylbutyl)-1-piperazinyl]-5-hydroxypyrimidin derivatives, their preparation and their use as medicines | ESTEVE LABOR DR (ES) | 2000-01-12 | — | — | EP | claimed |
| US-5444059-A | Anxiolytic agents | LABORATORIOS DEL. DR. ESTEVE, S.A. (ES) | 1995-08-22 | — | — | US | claimed |
| EP-0610140-A1 | 2- 4-(4-Azolylbutyl)-1-piperazinyl -5-hydroxypyrimidin derivatives, their preparation and their use als medicines | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1994-08-10 | — | — | EP | claimed |
| EP-0610140-B1 | 2-[4-(4-Azolylbutyl)-1-piperazinyl]-5-hydroxypyrimidin derivatives, their preparation and their use as medicines | ESTEVE LABOR DR (ES) | 2000-01-12 | — | — | EP | disclosed |
| US-5444059-A | Anxiolytic agents | LABORATORIOS DEL. DR. ESTEVE, S.A. (ES) | 1995-08-22 | — | — | US | disclosed |
| EP-0610140-A1 | 2- 4-(4-Azolylbutyl)-1-piperazinyl -5-hydroxypyrimidin derivatives, their preparation and their use als medicines | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1994-08-10 | — | — | EP | disclosed |