Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550858 | 0.86 | SIGMAR1 (0.50) | HRH3SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL7682702 | 0.77 | DRD2 (0.64) | HRH4HRH3DRD2DRD4DRD3 | |
| SCHEMBL7003873 | 0.76 | GPR84 (0.41) | HRH3DRD2DRD4DRD3 | |
| SCHEMBL28770942 | 0.76 | DRD2 (0.62) | HRH4HRH3DRD2DRD4DRD3 | |
| SCHEMBL8106008 | 0.75 | HTR1A (0.59) | HRH3HRH1SIGMAR1DRD2DRD4 | |
| SCHEMBL8955030 | 0.74 | GPR84 (0.44) | HRH3HRH1DRD2DRD4DRD3 | |
| SCHEMBL6670121 | 0.71 | HRH3 (0.53) | HRH3HRH1 | |
| SCHEMBL18926549 | 0.71 | LTA4H (0.59) | HRH3HRH1LTA4HSIGMAR1SLC6A3 | |
| SCHEMBL18917604 | 0.70 | LTA4H (0.75) | HRH3HRH1LTA4HSIGMAR1SLC6A3 | |
| SCHEMBL5302082 | 0.69 | LTA4H (0.86) | HRH3LTA4HSIGMAR1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108853102-B | Condensed acridine derivatives acting on Dectin-1 and uses thereof | 北京大学 | 2021-04-09 | — | — | CN | disclosed |