Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55493 | 0.82 | ALDH1A1 (0.60) | MTNR1AMTNR1BKMT2AMEN1TAS1R3 | |
| SCHEMBL9731367 | 0.81 | ALDH1A1 (0.60) | KMT2AMEN1TAS1R3TAS1R1TDP1 | |
| SCHEMBL9150411 | 0.79 | ACHE (0.52) | KMT2AMEN1TAS1R3TAS1R1TDP1 | |
| SCHEMBL20478656 | 0.74 | DRD4 (0.50) | MTNR1AMTNR1BKMT2AMEN1TAS1R3 | |
| SCHEMBL16536227 | 0.74 | LIPG (0.56) | KMT2AMEN1TAS1R3TAS1R1TDP1 | |
| SCHEMBL14376735 | 0.74 | ALDH1A1 (0.69) | KMT2AMEN1TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL81120 | 0.73 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL17296723 | 0.73 | TDP1 (0.47) | KMT2AMEN1TAS1R3TAS1R1TDP1 | |
| SCHEMBL15577014 | 0.71 | DRD2 (0.49) | — | |
| SCHEMBL4014628 | 0.71 | MTNR1A (0.46) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071875-A | Nervous system, psychological disorders; sleep cycle, skin dis coloration | NORTHWESTERN UNIVERSITY (US) | 1991-12-10 | — | — | US | claimed |
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | claimed |
| EP-2120912-B1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE JUSTINE (CA) | 2013-04-03 | — | — | EP | disclosed |
| US-8222298-B2 | Methods of correcting imbalance between bone resorption and bone formation and kits and compositions therefor | CHU SAINTE-JUSTINE (CA) | 2012-07-17 | — | — | US | disclosed |
| US-20120135930-A1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE-JUSTINE | 2012-05-31 | — | — | US | disclosed |
| US-8129432-B2 | Method of correcting imbalance between bone resorption and bone formation and kits and compositions therefor | CHU SAINTE-JUSTINE (CA) | 2012-03-06 | — | — | US | disclosed |
| US-20100029567-A1 | METHOD OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE-JUSTINE (CA) | 2010-02-04 | — | — | US | disclosed |
| EP-2120912-A1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | Chu Sainte-justine (CA) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008098379-A1 | METHODS OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR | CHU SAINTE-JUSTINE (CA) | 2008-08-21 | — | — | WO | disclosed |
| US-5151446-A | Neurological disorders or cardiovascular disorders | NORTHWESTERN UNIVERSITY (US) | 1992-09-29 | — | — | US | disclosed |
| US-5071875-A | Nervous system, psychological disorders; sleep cycle, skin dis coloration | NORTHWESTERN UNIVERSITY (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | disclosed |