Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269321 | 0.78 | GRIK1 (0.56) | SMN1; SMN2NPC1RAB9AHPGDAHR | |
| SCHEMBL31184828 | 0.77 | CDK4 (0.41) | SMN1; SMN2NPC1RAB9AAHRPARP14 | |
| SCHEMBL5515054 | 0.77 | GRIK1 (0.51) | SMN1; SMN2NPC1RAB9AHPGDAHR | |
| SCHEMBL4413986 | 0.77 | MTNR1A (0.53) | SMN1; SMN2NPC1RAB9APOLBHPGD | |
| SCHEMBL31487774 | 0.77 | MTNR1A (0.53) | SMN1; SMN2NPC1RAB9APOLBHPGD | |
| SCHEMBL5493171 | 0.77 | KDM4E (0.51) | SMN1; SMN2NPC1RAB9AHPGDAHR | |
| SCHEMBL9121651 | 0.77 | FAAH (0.50) | SMN1; SMN2NPC1RAB9APOLBAHR | |
| SCHEMBL31184955 | 0.76 | AHR (0.39) | SMN1; SMN2POLBHPGDAHRLMNA | |
| SCHEMBL4410319 | 0.76 | DRD2 (0.49) | SMN1; SMN2NPC1RAB9AHPGDAHR | |
| SCHEMBL34461886 | 0.76 | DRD2 (0.49) | SMN1; SMN2NPC1RAB9AHPGDAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |