SCHEMBL812574

SCHEMBL812574

CONc1ccc(OC)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.64
NPC1 O15118 3/20 0.64
GAA P10253 3/20 0.64
MAPT P10636 3/20 0.64
L3MBTL1 Q9Y468 2/20 0.64
KDM4E B2RXH2 1/20 0.64
THRB P10828 1/20 0.64
MAPK1 P28482 1/20 0.64
RECQL P46063 1/20 0.64
NPSR1 Q6W5P4 1/20 0.64
TDP1 Q9NUW8 1/20 0.64
CA1 P00915 3/20 0.58
CA2 P00918 3/20 0.58
CA12 O43570 1/20 0.58
CA7 P43166 1/20 0.58
CA9 Q16790 1/20 0.58
CA14 Q9ULX7 1/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
NR4A1 P22736 1/20 0.52
TP53 P04637 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29910198 0.86 NPC1 (0.41) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL25275080 0.80 TDP1 (0.59) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL11222030 0.79 RAB9A (0.64) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL851498 0.78 RAB9A (0.70) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL39057 0.78 MAPT (1.00) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL1459772 0.78 MAPT (1.00) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL11146268 0.78 SMN1; SMN2 (0.44) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL14995939 0.77 NQO1 (0.61) RAB9ANPC1GAAMAPTKDM4E
SCHEMBL28520010 0.77 RAB9A (0.54) RAB9ANPC1GAAMAPTL3MBTL1
SCHEMBL20041022 0.77 HPGD (0.61) RAB9ANPC1MAPTMAPK1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120058720-A Preparation and application of 7-alkyl camptothecine derivative containing hydroxylamine structure substitution 杭州爱科瑞思生物医药有限公司 2025-05-30 CN disclosed
WO-2024143473-A1 DECOMPOSITION INHIBITOR FOR TRANSITION METAL OXIDANTS 株式会社トクヤマ 2024-07-04 WO disclosed
US-9791399-B2 Derivatization of carbon SCHLUMBERGER TECHNOLOGY CORPORATION (US) 2017-10-17 US disclosed
US-20140332412-A1 DERIVATIZATION OF CARBON SCHLUMBERGER TECHNOLOGY COPORATION (US) 2014-11-13 US disclosed
US-7968734-B2 Organocatalysts and methods of use in chemical synthesis STC.UNM (US) 2011-06-28 US disclosed
CN-1807413-B Carbazole sulfonamide derivative and its preparation method INST MED BIOTECHNOLOGY CAMS 2010-05-05 CN disclosed
US-20070244328-A1 Organocatalysts and Methods of Use in Chemical Synthesis STC.UNM (US) 2007-10-18 US disclosed
CN-1807413-A Carbazole sulfonamide derivative and its preparation method MEDICINE AND BIOENGINEERING IN (CN) 2006-07-26 CN disclosed
WO-2006007586-A1 ORGANOCATALYSTS AND METHODS OF USE IN CHEMICAL SYNTHESIS SCIENCE & TECHNOLOGY CORPORATION @ UNM (US) 2006-01-19 WO disclosed
US-5059620-A Antiarrhythmia agents THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1991-10-22 US disclosed
US-4923873-A ANTIARRHYTHMIA AGENTS; SIDE EFFECT REDUCTION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-05-08 US disclosed
US-4755527-A Aryl substituted aminomethyl benzene derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-07-05 US disclosed
US-4748184-A Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-31 US disclosed
US-4562201-A ANTIARRHYTHMIA AGNETS AMERICAN HOSPITAL SUPPLY CORPORATION (US) 1985-12-31 US disclosed
EP-0113778-A4 ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-06-06 EP disclosed
EP-0113778-A1 ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS. AMERICAN HOSPITAL SUPPLY CORP (US) 1984-07-25 EP disclosed
WO-1984000545-A1 ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS AMERICAN HOSPITAL SUPPLY CORP (US) 1984-02-16 WO disclosed
US-4224340-A Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds WILLIAM H. RORER, INC. (US) 1980-09-23 US disclosed
US-4214003-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1980-07-22 US disclosed
US-4153722-A ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE WILLIAM H. RORER, INC. (US) 1979-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070244328-A1 Organocatalysts and Methods of Use in Chemical Synthesis SCO2, CBR1, CBR3 RAB9A 1447/4885NPC1 902/4885GAA 4167/4885
US-20140332412-A1 DERIVATIZATION OF CARBON FTH1, CBR1, SDHB RAB9A 4278/4885NPC1 4423/4885GAA 3656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.