Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625311 | 0.86 | TAAR1 (0.56) | PNMTDPP4TAAR1HTR2ALOXL2 | |
| SCHEMBL20316645 | 0.86 | PNMT (0.52) | PNMTDPP4TAAR1HTR2ALOXL2 | |
| SCHEMBL10505751 | 0.81 | ALDH1A1 (0.39) | PNMTTAAR1HTR2AALDH1A1MAPT | |
| SCHEMBL5025509 | 0.81 | PNMT (0.46) | PNMTDPP4TAAR1HTR2ALOXL2 | |
| SCHEMBL394854 | 0.77 | LIPG (0.47) | PNMTDPP4TAAR1HTR2ATLR8 | |
| SCHEMBL5629736 | 0.77 | DPP4 (0.45) | PNMTDPP4TAAR1HTR2AKDM4E | |
| SCHEMBL18653967 | 0.77 | PNMT (0.43) | PNMTDPP4TAAR1HTR2ALOXL2 | |
| SCHEMBL7476524 | 0.77 | SIGMAR1 (0.42) | PNMTTAAR1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29405036 | 0.77 | PNMT (0.63) | PNMTDPP4TAAR1LOXL2KDM4E | |
| SCHEMBL15247 | 0.77 | PNMT (0.63) | PNMTDPP4TAAR1LOXL2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049701-A1 | TRICYCLIC INDOLENE SUBSTITUTED OXAZOLIDINONES | BAYER AG (DE) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999037652-A1 | TRICYCLIC INDOLENE SUBSTITUTED OXAZOLIDINONES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-29 | — | — | WO | disclosed |