Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128678 | 0.89 | LTA4H (0.39) | MAOBLTA4HMAPTTSHRLMNA | |
| SCHEMBL8125457 | 0.83 | ACHE (0.39) | MAPTALDH1A1 | |
| SCHEMBL8131840 | 0.78 | GPR3 (0.36) | MAOB | |
| SCHEMBL8124467 | 0.78 | LTA4H (0.38) | MAOBLTA4HTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8129595 | 0.76 | ACHE (0.35) | MAPTTSHRLMNAALDH1A1MEN1 | |
| SCHEMBL8144057 | 0.76 | PTGS1 (0.38) | MAOBLTA4HTSHRLMNAAKR1C3 | |
| SCHEMBL2262764 | 0.76 | DHODH (0.35) | MAOBMAPTLMNAALDH1A1BRD4 | |
| SCHEMBL16020781 | 0.76 | ACHE (0.34) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8315326 | 0.74 | MAOB (0.44) | MAOBLTA4HMAPTTSHRAKR1C3 | |
| SCHEMBL7703136 | 0.74 | LTA4H (0.46) | MAOBLTA4HMAPTTSHRAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |