Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PMM2 | O15305 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129685 | 0.86 | PDE10A (0.36) | ACHEPOLBMAPTMEN1ALDH1A1 | |
| SCHEMBL16020781 | 0.82 | ACHE (0.34) | ACHEPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL8125457 | 0.80 | ACHE (0.39) | ACHEMAPTALDH1A1RAPGEF4 | |
| SCHEMBL2320151 | 0.79 | NUDT1 (0.32) | ALDH1A1NUDT1TRPA1ATMKDM4E | |
| SCHEMBL8131840 | 0.79 | GPR3 (0.36) | — | |
| SCHEMBL10892285 | 0.77 | ALDH1A1 (0.34) | MAPTALDH1A1NUDT1KDM4EALOX15 | |
| SCHEMBL9650055 | 0.77 | PTGS2 (0.37) | ACHE | |
| SCHEMBL8128129 | 0.76 | MAOB (0.38) | MAPTMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL982199 | 0.76 | TRPA1 (0.37) | ACHEMEN1ALDH1A1KMT2ANUDT1 | |
| SCHEMBL8907524 | 0.75 | PIK3R1 (0.33) | SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |