Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139674 | 0.88 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1AKR1B1 | |
| SCHEMBL8137807 | 0.87 | CYP1A2 (0.43) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL8144705 | 0.81 | KDM4C (0.37) | MAPTGAA | |
| SCHEMBL8566099 | 0.77 | LTA4H (0.39) | MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL10407545 | 0.77 | HSP90AA1 (0.38) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL8139680 | 0.74 | STAT3 (0.38) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL8143247 | 0.74 | PPARG (0.46) | AKR1B1 | |
| SCHEMBL12211579 | 0.72 | HSP90AA1 (0.40) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL6339100 | 0.72 | KCNE1 (0.45) | MEN1KMT2ARAB9AMAPTMAPK1 | |
| SCHEMBL6339097 | 0.72 | KCNE1 (0.45) | MEN1KMT2ARAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019412-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT 1D? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | EP | disclosed |
| US-5972935-A | Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-10-26 | — | — | US | disclosed |
| WO-1997007120-A9 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | — | 1997-04-03 | — | — | WO | disclosed |
| WO-1997007120-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-27 | — | — | WO | disclosed |