SCHEMBL8144705

SCHEMBL8144705

CN(C)C(=O)CC1CCOc2ccc(N)cc21

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 4/20 0.37
MTNR1A P48039 1/20 0.37
MTNR1B P49286 1/20 0.37
HTR1A P08908 2/20 0.34
HTR1D P28221 1/20 0.34
HTR2C P28335 1/20 0.34
SLC6A2 P23975 3/20 0.34
SLC6A4 P31645 3/20 0.34
CYP11B1 P15538 2/20 0.34
CYP11B2 P19099 2/20 0.34
KDM4E B2RXH2 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
MAP3K14 Q99558 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8139594 0.87 HTR1A (0.44) HTR1AHTR1DHTR2CMAP3K14
SCHEMBL8566099 0.81 LTA4H (0.39) KDM4CGAAPTGDR2
SCHEMBL8129090 0.81 MEN1 (0.39) GAAMAPT
SCHEMBL8139731 0.77 MTNR1A (0.36) KDM4CMTNR1AMTNR1BHTR1AHTR1D
SCHEMBL8616324 0.75 ACHE (0.46) MTNR1AMTNR1BCYP11B1CYP11B2
SCHEMBL8563821 0.74 HTR1A (0.35) KDM4CHTR1ACYP11B1CYP11B2GAA
SCHEMBL8144708 0.74 HTR1A (0.37) KDM4CMTNR1AMTNR1BHTR1AHTR1D
SCHEMBL28003359 0.72 KDM4C (0.51) KDM4CMTNR1AMTNR1BHTR1AHTR1D
SCHEMBL8794011 0.71 KDM4C (0.41) KDM4CMTNR1AMTNR1BHTR1AGAA
SCHEMBL13234014 0.70 MTNR1A (0.32) KDM4CMTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019412-A1 BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT 1D? RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-07-19 EP disclosed
US-5972935-A Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT1D receptor antagonists SMITHKLINE BEECHAM P.L.C. (GB) 1999-10-26 US disclosed
US-5756496-A Amide derivatives having 5HT1D-antagonist activity SMITHKLINE BEECHAM P.L.C. (GB) 1998-05-26 US disclosed
WO-1997007120-A9 BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS 1997-04-03 WO disclosed
EP-0763034-A1 AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1997-03-19 EP disclosed
WO-1997007120-A1 BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-02-27 WO disclosed
WO-1995032967-A1 AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1995-12-07 WO disclosed