Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8123568 | 0.88 | NR1H2 (0.40) | CALM1SMN1; SMN2ALDH1A1RAB9APTPN5 | |
| SCHEMBL8489407 | 0.85 | ALDH1A1 (0.36) | CALM1IDH1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL1371003 | 0.81 | TP53 (0.43) | SMN1; SMN2ALDH1A1RAB9AL3MBTL1BCL2 | |
| SCHEMBL5496841 | 0.81 | TSHR (0.43) | IDH1ACMSDLTA4H | |
| SCHEMBL1370523 | 0.78 | CNR1 (0.35) | SMN1; SMN2ALDH1A1RAB9ACA1CA2 | |
| SCHEMBL9952077 | 0.78 | FFAR1 (0.43) | LTA4H | |
| SCHEMBL8130799 | 0.78 | NPC1 (0.41) | CALM1IDH1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL2093279 | 0.76 | CALM1 (0.50) | CALM1IDH1PRSS1PRSS2PRSS3 | |
| SCHEMBL1368971 | 0.75 | HSD11B1 (0.46) | RAB9A | |
| SCHEMBL1535844 | 0.74 | ALDH1A1 (0.38) | ALDH1A1RAB9AACMSDPRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |