Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8124822 | 0.89 | ATM (0.37) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL8129279 | 0.78 | CALM1 (0.46) | RAB9ASMN1; SMN2TDP1L3MBTL1CALM1 | |
| SCHEMBL3912578 | 0.75 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL2093039 | 0.75 | CALM1 (0.48) | CALM1IDH1TP53BCL2BCL2L1 | |
| SCHEMBL7467097 | 0.75 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL8129685 | 0.73 | PDE10A (0.36) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL9004856 | 0.73 | ESR2 (0.39) | NPC1RAB9ASMN1; SMN2HPGDATM | |
| SCHEMBL9523594 | 0.73 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL5201643 | 0.73 | PLA2G7 (0.43) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL8128678 | 0.71 | LTA4H (0.39) | TDP1L3MBTL1TSHRALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |