Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129595 | 0.86 | ACHE (0.35) | MAPTPOLBMAPK1MEN1KMT2A | |
| SCHEMBL9650055 | 0.83 | PTGS2 (0.37) | PDE10APDE2AACHE | |
| SCHEMBL3912578 | 0.81 | NPC1 (0.35) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL434431 | 0.81 | L3MBTL1 (0.38) | ALDH1A1KDM4ECYP1A2HPGDNPC1 | |
| SCHEMBL8125196 | 0.79 | CYP1A2 (0.40) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL9138237 | 0.78 | HSD11B1 (0.41) | PDE10APDE2APOLBMAPK1MEN1 | |
| SCHEMBL9523594 | 0.78 | NPC1 (0.40) | PDE10APDE2AMAPTMAPK1MEN1 | |
| SCHEMBL5201643 | 0.78 | PLA2G7 (0.43) | MAPTPOLBMAPK1MEN1KMT2A | |
| SCHEMBL8077591 | 0.78 | PTGS2 (0.36) | MAPTMAPK1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9004856 | 0.78 | ESR2 (0.39) | MAPTPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |