Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | DGKA | P23743 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14607144 | 0.84 | CA12 (0.35) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL11129242 | 0.84 | MET (0.37) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2256279 | 0.80 | MMP1 (0.41) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL26270357 | 0.79 | TSHR (0.36) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9936197 | 0.78 | TSHR (0.38) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL10477474 | 0.77 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4TDP1DGKA | |
| SCHEMBL22115803 | 0.77 | TSHR (0.37) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL22115766 | 0.77 | TSHR (0.39) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL15383208 | 0.77 | TSHR (0.37) | TSHRMETALDH1A1CYP3A4ALOX15 | |
| SCHEMBL14607143 | 0.76 | RECQL (0.45) | TSHRMETALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962784-B2 | Isocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8470954-B2 | Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8324292-B2 | Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant | ETHICON, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8071663-B2 | Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant | ETHICON, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-7968668-B2 | Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100158849-A1 | ISOCYANATE TERMINATED MACROMER AND FORMULATION THEREOF FOR USE AS AN INTERNAL ADHESIVE OR SEALANT | ETHICON, INC. | 2010-06-24 | — | — | US | disclosed |
| US-7728097-B2 | Method of making a diisocyanate terminated macromer | ETHICON, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20090222038-A1 | MEDICALLY ACCEPTABLE FORMULATION OF A DIISOCYANATE TERMINATED MACROMER FOR USE AS AN INTERNAL ADHESIVE OR SEALANT | ETHICON, INC. | 2009-09-03 | — | — | US | disclosed |
| US-20090221731-A1 | MEDICALLY ACCEPTABLE FORMULATION OF A DIISOCYANATE TERMINATED MACROMER FOR USE AS AN INTERNAL ADHESIVE OR SEALANT | ETHICON, INC. | 2009-09-03 | — | — | US | disclosed |
| US-20070276121-A1 | DIISOCYANATE TERMINATED MACROMER AND FORMULATION THEREOF FOR USE AS AN INTERNAL ADHESIVE OR SEALANT | ETHICON, INC. | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100158849-A1 | ISOCYANATE TERMINATED MACROMER AND FORMULATION THEREOF FOR USE AS AN INTERNAL ADHESIVE OR SEALANT | ICAM1, ILK, MACF1 | TSHR 4859/4885MET 2185/4885ALDH1A1 517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.