Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PRF1 | P14222 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125734 | 0.89 | ALDH1A1 (0.35) | MEN1KMT2APRF1SIRT2PARG | |
| SCHEMBL8125730 | 0.89 | ALDH1A1 (0.35) | MEN1KMT2APRF1SIRT2PARG | |
| SCHEMBL8126389 | 0.84 | IKBKB (0.40) | ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL8141677 | 0.84 | BRD4 (0.44) | LMNAHTR6DRD2HTR2AHTR2C | |
| SCHEMBL8133530 | 0.84 | PTGS2 (0.40) | HTR6GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4370479 | 0.83 | HTR6 (0.47) | MEN1KMT2AALDH1A1LMNAHTR6 | |
| SCHEMBL6609340 | 0.82 | CASP3 (0.47) | MEN1KMT2ALMNAHTR6 | |
| SCHEMBL8134987 | 0.81 | SMN1; SMN2 (0.42) | MEN1KMT2AALDH1A1LMNAHTR6 | |
| SCHEMBL8102934 | 0.81 | CES1 (0.39) | MEN1KMT2AALDH1A1LMNAHTR6 | |
| SCHEMBL13592440 | 0.81 | GRIA1 (0.36) | ALDH1A1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781285-B1 | FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE AS GLUTAMATE ANTAGONISTS | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | disclosed |
| WO-1996008495-A1 | FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1996-03-21 | — | — | WO | disclosed |