SCHEMBL8140247

SCHEMBL8140247

Cn1c(=O)n(-c2ccc(O)cc2F)c(=O)n1C(F)F

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 7/20 0.42
ESR2 Q92731 4/20 0.42
HSP90AA1 P07900 1/20 0.33
MYC P01106 1/20 0.31
PTPN1 P18031 1/20 0.31
GLA P06280 1/20 0.31
EGFR P00533 1/20 0.31
AR P10275 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979612 0.79 L3MBTL1 (0.40) GLAL3MBTL1
SCHEMBL7994197 0.71 MAPT (0.38)
SCHEMBL7844919 0.69 PPOX (0.46) ESR1ESR2
SCHEMBL9114198 0.67 ESR1 (0.40) ESR1ESR2HSP90AA1MYCPTPN1
SCHEMBL8476477 0.66 ESR1 (0.42) ESR1ESR2AR
SCHEMBL8580312 0.63 L3MBTL1 (0.43) ESR1ESR2ARL3MBTL1
SCHEMBL8579780 0.62 GRM4 (0.52) ESR1ESR2
SCHEMBL16965765 0.61 ESR1 (0.46) ESR1ESR2HSP90AA1
SCHEMBL12362758 0.61 ESR1 (0.36) ESR1ESR2HSP90AA1EGFRAR
SCHEMBL9218640 0.60 ESR1 (0.46) ESR1ESR2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051414-A1 SUBSTITUTED HETEROARYLMETHYL COMPOUNDS USED AS HERBICIDES Bayer Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999038861-A1 SUBSTITUTED HETEROARYLMETHYL COMPOUNDS USED AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1999-08-05 WO disclosed