Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8151368 | 0.88 | HSD11B1 (0.45) | ALDH1A1SMN1; SMN2TDP1LMNAHDAC4 | |
| SCHEMBL8223202 | 0.79 | OPRM1 (0.38) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8226372 | 0.79 | AKR1C1 (0.40) | ALDH1A1SMN1; SMN2TDP1HDAC4HSD11B1 | |
| SCHEMBL8151416 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAP4K4SMN1; SMN2RAB9AP2RX7 | |
| SCHEMBL4747010 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAP4K4SMN1; SMN2RAB9AP2RX7 | |
| SCHEMBL5845417 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAP4K4P2RX7POLBLMNA | |
| SCHEMBL2701341 | 0.76 | ALDH1A1 (0.54) | ALDH1A1MAP4K4P2RX7POLBLMNA | |
| SCHEMBL1625869 | 0.72 | MAP4K4 (0.61) | ALDH1A1MAP4K4P2RX7POLBLMNA | |
| SCHEMBL15349038 | 0.71 | ALDH1A1 (0.48) | ALDH1A1MAP4K4P2RX7POLBLMNA | |
| SCHEMBL29539745 | 0.68 | TDP1 (0.40) | SMN1; SMN2TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117148-A1 | SUBSTITUTED OXADIAZOLE ANALOGS AS CALCIUM CHANNEL ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-10-02 | — | — | WO | disclosed |