Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO known ✓ | Q99835 | 1/20 | 0.38 |
| ▸ | BTK known ✓ | Q06187 | 3/20 | 0.37 |
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 known ✓ | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 known ✓ | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 known ✓ | P52333 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8143988 | 1.00 | FTO (0.40) | FTONAMPTSCN9ASMOPTGER1 | |
| SCHEMBL9304657 | 0.90 | KIF11 (0.41) | NAMPTSCN9ASMOPTGER1JAK2 | |
| Fumaric Acid SCHEMBL9258066 | 0.84 | HSD17B10 (0.44) | NAMPTPTGER1BTKHSD17B10KDM4E | |
| Fumaric Acid SCHEMBL9258073 | 0.84 | HSD17B10 (0.44) | NAMPTPTGER1BTKHSD17B10KDM4E | |
| SCHEMBL9305227 | 0.83 | KIF11 (0.40) | NAMPTSCN9ASMOHSD17B10KDM4E | |
| Maleic Acid SCHEMBL8135697 | 0.82 | TEAD2 (0.37) | NAMPTPTGER1BTKHSD17B10KDM4E | |
| Fumaric Acid SCHEMBL8135703 | 0.82 | TEAD2 (0.37) | NAMPTPTGER1BTKHSD17B10KDM4E | |
| SCHEMBL9304368 | 0.82 | MERTK (0.39) | NAMPTSCN9AHSD17B10KDM4ETSHR | |
| SCHEMBL9258008 | 0.79 | NAMPT (0.39) | NAMPTBTKHSD17B10KDM4ETSHR | |
| Fumaric Acid SCHEMBL8138733 | 0.77 | TEAD2 (0.40) | NAMPTPTGER1BTKHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594001-B1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2000-08-16 | — | — | EP | disclosed |