Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9305227 | 0.93 | KIF11 (0.40) | KIF11SRCBRAFKDRMAPK14 | |
| SCHEMBL9304368 | 0.91 | MERTK (0.39) | KIF11SRCBRAFKDRMAPK14 | |
| Maleic Acid SCHEMBL8143988 | 0.90 | FTO (0.40) | KIF11NAMPTSCN9AJAK2JAK1 | |
| Fumaric Acid SCHEMBL8143990 | 0.90 | FTO (0.40) | KIF11NAMPTSCN9AJAK2JAK1 | |
| SCHEMBL9258008 | 0.88 | NAMPT (0.39) | MAPK14MERTKNAMPTMAOBKDM4E | |
| SCHEMBL9302703 | 0.83 | CSNK2A2 (0.39) | SRCBRAFKDRNAMPTKCNH2 | |
| SCHEMBL8137072 | 0.83 | ALDH1A1 (0.39) | NAMPTMAOBKDM4ENPSR1 | |
| SCHEMBL9306122 | 0.82 | HSD17B10 (0.47) | MERTKMAOBKDM4E | |
| Hydrochloric Acid SCHEMBL8134231 | 0.81 | HSD17B10 (0.46) | MERTKMAOBKDM4E | |
| SCHEMBL9304792 | 0.80 | MAPK13 (0.41) | BRAFMAPK14MERTKNAMPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |