Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8155235 | 0.79 | OPRL1 (0.42) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL27923823 | 0.76 | L3MBTL1 (0.42) | SLC18A3KDM4ECHRM2CHRM5CHRM3 | |
| SCHEMBL27528187 | 0.74 | HRH3 (0.41) | KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL24501917 | 0.73 | CTSL (0.38) | CTSLCTSK | |
| SCHEMBL1306525 | 0.73 | CTSL (0.38) | CTSLCTSK | |
| SCHEMBL1307610 | 0.73 | VCP (0.35) | CTSLCTSK | |
| SCHEMBL3630604 | 0.73 | VCP (0.35) | CTSLCTSK | |
| SCHEMBL28203430 | 0.72 | ALDH1A1 (0.36) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL5950982 | 0.72 | L3MBTL1 (0.52) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3953970 | 0.72 | CA1 (0.44) | KDM4ECTSLCTSKATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |