Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8156114 | 0.85 | CHRM2 (0.38) | MAPTALDH1A1 | |
| SCHEMBL8153452 | 0.83 | LMNA (0.32) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL1388713 | 0.82 | TDP1 (0.40) | LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8910755 | 0.82 | TSHR (0.33) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL8154324 | 0.81 | LMNA (0.35) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL8150139 | 0.79 | RAB9A (0.33) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL8910147 | 0.79 | LMNA (0.31) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL8155851 | 0.78 | CHRNB2 (0.36) | MAPTSMN1; SMN2 | |
| SCHEMBL8150388 | 0.78 | LMNA (0.32) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL9434967 | 0.78 | MAPT (0.42) | HTTLMNAMAPTSMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | claimed |
| US-6013807-A | Antitumor tetracyclic compounds | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2000-01-11 | — | — | US | disclosed |
| US-5852204-A | Pyrrolo 3,2-b-!-carbazoles and 1H 1!benzothieno 2,3-f! indoles having anti-tumor activity | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-12-22 | — | — | US | disclosed |
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |