Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR known ✓ | Q92847 | 15/20 | 0.57 |
| ▸ | TACR1 known ✓ | P25103 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759453 | 0.91 | GHSR (0.51) | GHSRTACR1 | |
| SCHEMBL7495162 | 0.88 | GHSR (0.44) | GHSRTACR1 | |
| SCHEMBL7918487 | 0.86 | GHSR (0.43) | GHSRTACR1 | |
| SCHEMBL7500323 | 0.83 | GHSR (0.55) | GHSRTACR1 | |
| SCHEMBL7868472 | 0.83 | GHSR (0.40) | GHSR | |
| SCHEMBL8469385 | 0.82 | GHSR (0.56) | GHSRTACR1 | |
| Hydrochloric Acid SCHEMBL8590141 | 0.81 | GHSR (0.38) | GHSR | |
| Hydrochloric Acid SCHEMBL7571947 | 0.76 | GHSR (0.41) | GHSRTACR1 | |
| Hydrochloric Acid SCHEMBL9391073 | 0.76 | GHSR (0.48) | GHSR | |
| SCHEMBL16539832 | 0.76 | HTR2C (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019402-A1 | POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE | Merck & Co., Inc. (US) | 2000-07-19 | — | — | EP | disclosed |
| EP-0857020-A4 | WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE | MERCK & CO INC (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0857020-A1 | WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE | Merck & Co., Inc. (US) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015191-A1 | WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |
| WO-1997015574-A1 | POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |