SCHEMBL8154595

SCHEMBL8154595

CC(C)(C)O[PH](=O)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.35
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MAPK1 P28482 1/20 0.34
ALOX15 P16050 1/20 0.32
MAPT P10636 1/20 0.30
KMT2A Q03164 1/20 0.30
PRSS1 P07477 1/20 0.30
CTSG P08311 1/20 0.30
CTRB1 P17538 1/20 0.30
CMA1 P23946 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL258394 0.73 CA4 (0.38) ALDH1A1TSHRTDP1MAPK1ALOX15
SCHEMBL2895052 0.72 ALDH1A1 (0.32) ALDH1A1TSHR
SCHEMBL3666357 0.71 CA4 (0.36) ALDH1A1TSHRTDP1ALOX15MAPT
SCHEMBL258348 0.71 CA4 (0.36) ALDH1A1TSHRTDP1ALOX15MAPT
SCHEMBL258618 0.71 CA4 (0.36) ALDH1A1TSHRTDP1ALOX15MAPT
SCHEMBL258292 0.71 CA4 (0.36) ALDH1A1TSHRTDP1ALOX15MAPT
SCHEMBL258478 0.71 CA4 (0.36) ALDH1A1TSHRTDP1ALOX15MAPT
SCHEMBL30883026 0.71 ELANE (0.42) ALDH1A1TSHRHSD17B10TDP1MAPT
SCHEMBL2155675 0.69 ALDH1A1 (0.33) ALDH1A1TSHRHSD17B10TDP1
SCHEMBL1683358 0.69 MAPK1 (0.33) ALDH1A1TSHRHSD17B10TDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114181250-A Alkenyl phosphine compound and preparation method thereof 中国石油化工股份有限公司 2022-03-15 CN claimed
US-6028216-A Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives GUILFORD PHARMACEUTICALS INC. (US) 2000-02-22 US claimed
WO-1999033848-B1 PROCESS FOR PREPARING ENANTIOMER-ENRICHED HYDROXYPHOSPHINYL DERIVATIVES GUILFORD PHARM INC (US) 1999-08-12 WO claimed
WO-1999033848-A1 PROCESS FOR PREPARING ENANTIOMER-ENRICHED HYDROXYPHOSPHINYL DERIVATIVES GUILFORD PHARMACEUTICALS INC. (US) 1999-07-08 WO claimed
CN-114181250-A Alkenyl phosphine compound and preparation method thereof 中国石油化工股份有限公司 2022-03-15 CN disclosed
CN-107949564-B Method for producing alkenyl phosphorus compound 丸善石油化学株式会社 2019-11-29 CN disclosed
US-10479809-B2 Method for producing alkenyl phosphorus compound MARUZEN PETROCHEMICAL CO., LTD. (JP) 2019-11-19 US disclosed
US-20190263847-A1 METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND MARUZEN PETROCHEMICAL CO., LTD. (JP) 2019-08-29 US disclosed
EP-3348561-A1 METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND Maruzen Petrochemical Co., Ltd. (JP) 2018-07-18 EP disclosed
CN-107949564-A METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND 丸善石油化学株式会社 2018-04-20 CN disclosed
US-9725552-B2 HMF-based phenol formaldehyde resin INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-08-08 US disclosed
US-20160102165-A1 HMF-BASED PHENOL FORMALDEHYDE RESIN INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2016-04-14 US disclosed
US-20090163444-A1 PHOSPHO-INDOLES AS HIV INHIBITORS IDENIX PHARMACEUTICALS LLC 2009-06-25 US disclosed
US-6028216-A Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives GUILFORD PHARMACEUTICALS INC. (US) 2000-02-22 US disclosed
WO-1999033848-A1 PROCESS FOR PREPARING ENANTIOMER-ENRICHED HYDROXYPHOSPHINYL DERIVATIVES GUILFORD PHARMACEUTICALS INC. (US) 1999-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090163444-A1 PHOSPHO-INDOLES AS HIV INHIBITORS IDO1, PPP5C, INMT ALDH1A1 4061/4885TSHR 4573/4885HSD17B10 3538/4885
US-10479809-B2 Method for producing alkenyl phosphorus compound ORC3, OR10J3, ORAI3 ALDH1A1 1706/4885TSHR 1438/4885HSD17B10 1252/4885
US-20190263847-A1 METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND ORC3, OR10J3, ALK ALDH1A1 1631/4885TSHR 1162/4885HSD17B10 1083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.