Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105863 | 0.81 | ALDH1A1 (0.46) | LMNATP53MAPTL3MBTL1KDM2B | |
| SCHEMBL8154751 | 0.81 | KCNH2 (0.50) | LMNATP53MAPTL3MBTL1MGLL | |
| SCHEMBL8109646 | 0.80 | MGLL (0.43) | LMNATP53MAPTL3MBTL1KDM2B | |
| SCHEMBL8105639 | 0.80 | KMT2A (0.43) | LMNATP53MAPTL3MBTL1KCNH2 | |
| SCHEMBL8149813 | 0.80 | KCNH2 (0.44) | LMNATP53MAPTL3MBTL1MGLL | |
| SCHEMBL8096311 | 0.79 | MGLL (0.42) | LMNATP53MAPTL3MBTL1KDM2B | |
| SCHEMBL2297101 | 0.72 | MGLL (0.58) | LMNATP53MAPTL3MBTL1MGLL | |
| (4-Chlorophenyl)(Cyclopropyl)Methanone SCHEMBL392801 | 0.69 | MGLL (0.68) | LMNATP53MAPTL3MBTL1MGLL | |
| SCHEMBL8111507 | 0.68 | MGLL (0.47) | LMNATP53MAPTL3MBTL1KDM2B | |
| SCHEMBL30342141 | 0.67 | MGLL (0.52) | LMNATP53MAPTL3MBTL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |