Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149813 | 0.85 | KCNH2 (0.44) | ALDH1A1LMNAKCNH2MGLLKMT2A | |
| SCHEMBL8155669 | 0.81 | LMNA (0.47) | LMNAKCNH2MGLLKMT2AMEN1 | |
| SCHEMBL8154751 | 0.80 | KCNH2 (0.50) | LMNAKCNH2MGLLKMT2AMEN1 | |
| SCHEMBL8105639 | 0.74 | KMT2A (0.43) | ALDH1A1LMNAKCNH2KMT2ASMN1; SMN2 | |
| SCHEMBL8109646 | 0.73 | MGLL (0.43) | LMNAMGLLKMT2AMEN1MAPT | |
| SCHEMBL8096311 | 0.72 | MGLL (0.42) | LMNAMGLLKMT2AMEN1MAPT | |
| SCHEMBL8105866 | 0.67 | MGLL (0.56) | ALDH1A1KCNH2MGLLKMT2AMEN1 | |
| SCHEMBL8557472 | 0.66 | KMT2A (0.50) | ALDH1A1LMNAKCNH2MGLLKMT2A | |
| SCHEMBL2297101 | 0.65 | MGLL (0.58) | LMNAMGLLKMT2AMEN1MAPT | |
| (4-Chlorophenyl)(Cyclopropyl)Methanone SCHEMBL6220062 | 0.63 | MGLL (0.64) | LMNAKCNH2MGLLKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |