Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149813 | 0.82 | KCNH2 (0.44) | KCNH2MGLLMEN1KMT2ACYP1A2 | |
| SCHEMBL8155669 | 0.81 | LMNA (0.47) | KCNH2MGLLMEN1KMT2ALMNA | |
| SCHEMBL8105863 | 0.80 | ALDH1A1 (0.46) | KCNH2MGLLMEN1KMT2ALMNA | |
| SCHEMBL8105639 | 0.78 | KMT2A (0.43) | KCNH2KMT2ALMNATP53MAPT | |
| SCHEMBL8109646 | 0.72 | MGLL (0.43) | MGLLMEN1KMT2ALMNATP53 | |
| SCHEMBL8096311 | 0.71 | MGLL (0.42) | MGLLMEN1KMT2ALMNATP53 | |
| SCHEMBL8557472 | 0.65 | KMT2A (0.50) | KCNH2MGLLMEN1KMT2ACYP1A2 | |
| SCHEMBL14391641 | 0.65 | POLB (0.67) | KCNH2MGLLHTR2AMEN1KMT2A | |
| SCHEMBL2297101 | 0.65 | MGLL (0.58) | MGLLMEN1KMT2ALMNATP53 | |
| (4-Chlorophenyl)(Cyclopropyl)Methanone SCHEMBL6220062 | 0.62 | MGLL (0.64) | KCNH2MGLLMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |