Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 7/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178641 | 0.85 | ADRA1D (0.49) | HCRTR2HTR2BKDM1ALMNAHCRTR1 | |
| SCHEMBL8173512 | 0.82 | HTR2B (0.46) | HCRTR2HTR2BKDM1ATHRBLMNA | |
| SCHEMBL8166794 | 0.78 | ADRA1D (0.57) | LMNAMAPTMAPK1ALDH1A1ALOX15 | |
| SCHEMBL8174233 | 0.78 | ADRA1D (0.45) | HCRTR2HTR2BLMNAMAPTMAPK1 | |
| SCHEMBL8174185 | 0.74 | LMNA (0.45) | HTR2BLMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL8174151 | 0.72 | ADRA1D (0.72) | POLBTP53 | |
| SCHEMBL8174400 | 0.69 | CASP6 (0.39) | HCRTR2KDM1A | |
| SCHEMBL13157594 | 0.68 | NR4A2 (0.49) | HTR2BLMNAPOLBALDH1A1ALOX15 | |
| SCHEMBL18711625 | 0.68 | SPR (0.49) | HCRTR2HTR2BKDM1ALMNAHCRTR1 | |
| SCHEMBL8174797 | 0.68 | CYP2C9 (0.51) | HCRTR2HTR2BLMNAHCRTR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |