Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
| ▸ | CHRNG | P07510 | 1/20 | 0.43 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CHRND | Q07001 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311821 | 0.83 | SLC6A2 (0.47) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL4073117 | 0.81 | SLC6A3 (0.40) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL655610 | 0.81 | DRD2 (0.53) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL4885831 | 0.81 | SLC6A3 (0.40) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL4603160 | 0.81 | OPRM1 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL11768776 | 0.81 | OPRM1 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| Hydrochloric Acid SCHEMBL16799773 | 0.80 | HTR2C (0.39) | HTR2CHTR2AHTR2BSLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL18038830 | 0.80 | OPRM1 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL11119002 | 0.78 | HSD11B1 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4MAOA | |
| SCHEMBL1921194 | 0.78 | CHRNB2 (0.47) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071932-A | SUPPRESSING ABSORPTION OF GAMMA-AMINOBUTYRIC ACID FOR TREATMENT OF NERVOUS SYSTEM DISORDERS | BRITISH TECHNOLOGY GROUP INTERCORPORATE LICENSING LIMITED (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0823905-A1 | NOVEL HETEROCYCLIC CHEMISTRY | NOVO NORDISK A/S (DK) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034863-A1 | NOVEL HETEROCYCLIC CHEMISTRY | NOVO NORDISK A/S (DK) | 1996-11-07 | — | — | WO | disclosed |