Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507439 | 0.79 | HSD11B1 (0.40) | HSD11B1CXCR3 | |
| SCHEMBL331455 | 0.67 | — | — | |
| SCHEMBL629269 | 0.65 | APLNR (0.38) | CYP2C9 | |
| SCHEMBL31226476 | 0.62 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL3250801 | 0.62 | NAAA (0.33) | — | |
| SCHEMBL186771 | 0.60 | CYP2C9 (0.44) | HSD11B1CYP2C9 | |
| SCHEMBL8180865 | 0.60 | TGM2 (0.42) | HSD11B1TGM2 | |
| SCHEMBL354701 | 0.60 | HSD11B1 (0.39) | HSD11B1CYP2C9 | |
| SCHEMBL339411 | 0.60 | HSD11B1 (0.44) | HSD11B1CYP2C9 | |
| SCHEMBL20180015 | 0.60 | HSD11B1 (0.44) | HSD11B1CXCR3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071935-A | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0907649-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049700-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |