Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22925906 | 0.84 | KIF11 (0.46) | LMNATHRBKIF11TRPV1TRPM8 | |
| SCHEMBL472556 | 0.83 | MAPT (0.41) | LMNATHRBMAPTKIF11TRPV1 | |
| SCHEMBL8192268 | 0.80 | BRD4 (0.50) | LMNAMAPTNR1H4NOTUM | |
| SCHEMBL5545503 | 0.79 | PTGS2 (0.54) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL29154647 | 0.79 | MAPK13 (0.68) | MAPTKIF11MAPK13MAPK12MAPK11 | |
| SCHEMBL8192267 | 0.79 | ENPP3 (0.42) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4741182 | 0.78 | IKBKB (0.45) | MAPTTRPV1PTPN1 | |
| SCHEMBL5546174 | 0.76 | CCR9 (0.44) | LMNAMAPTNR1H4MAPK13MAPK12 | |
| SCHEMBL9434736 | 0.76 | NPC1 (0.39) | LMNAMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL21051602 | 0.76 | NPC1 (0.40) | MAPTNR1H4MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |