Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195776 | 0.93 | CA2 (0.41) | CA2EDNRBEDNRAPTGS2PTGS1 | |
| SCHEMBL8188366 | 0.92 | CA2 (0.43) | CA2PTGS2LOX | |
| SCHEMBL8196926 | 0.91 | CA2 (0.42) | CA2PTGS2PTGS1LOXKMT2A | |
| SCHEMBL8196062 | 0.91 | ALDH1A1 (0.46) | CA2PTGS2NPC1KMT2ALMNA | |
| SCHEMBL8196195 | 0.88 | PTGS2 (0.40) | CA2TBXA2RPTGS2PTGDR2 | |
| SCHEMBL8188503 | 0.85 | PTGS2 (0.40) | CA2PTGS2PTGS1PTGDR2 | |
| SCHEMBL8196899 | 0.84 | PTGS2 (0.39) | CA2PTGS2PTGS1PTGDR2 | |
| SCHEMBL8200031 | 0.84 | PTGS2 (0.39) | CA2PTGS2PTGS1PTGDR2LMNA | |
| SCHEMBL8196142 | 0.82 | PTGS2 (0.37) | CA2PTGS2PTGS1PTGDR2 | |
| SCHEMBL8188096 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1PTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |