Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 8/20 | 0.39 |
| ▸ | MMP2 | P08253 | 5/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 12/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 4/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198041 | 0.89 | MMP2 (0.39) | MMP3MMP2MMP1MMP13MMP9 | |
| SCHEMBL8422672 | 0.85 | GAA (0.39) | GAAMMP3MMP2MMP1ACE | |
| SCHEMBL8197792 | 0.83 | MMP3 (0.38) | MMP3MMP2ALOX5MMP1MMP13 | |
| SCHEMBL8197867 | 0.82 | MMP3 (0.38) | MMP3MMP2ALOX5MMP1MMP13 | |
| SCHEMBL6416552 | 0.80 | MMP1 (0.54) | MMP3MMP2MMP1MMP13MMP9 | |
| SCHEMBL6411900 | 0.75 | MMP3 (0.42) | MMP3MMP2MMP1MMP13MMP9 | |
| SCHEMBL8200744 | 0.73 | KDM4C (0.34) | MMP3MMP2MMP1MMP13MMP9 | |
| SCHEMBL7358479 | 0.72 | ALOX5 (0.44) | MMP3MMP2ALOX5MMP1MMP13 | |
| SCHEMBL23997631 | 0.72 | SAE1 (0.46) | GAAMMP3MMP1ACEMMP9 | |
| SCHEMBL8200251 | 0.70 | KDM4C (0.33) | MMP3MMP2MMP1MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017889-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-01-25 | — | — | US | disclosed |
| EP-0740655-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-10-20 | — | — | EP | disclosed |
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |