Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 15/20 | 0.31 |
| ▸ | MMP1 | P03956 | 14/20 | 0.31 |
| ▸ | MMP2 | P08253 | 12/20 | 0.31 |
| ▸ | MMP9 | P14780 | 9/20 | 0.31 |
| ▸ | MMP8 | P22894 | 4/20 | 0.31 |
| ▸ | MMP13 | P45452 | 3/20 | 0.31 |
| ▸ | MMP7 | P09237 | 3/20 | 0.30 |
| ▸ | MMP14 | P50281 | 2/20 | 0.30 |
| ▸ | TNF | P01375 | 2/20 | 0.30 |
| ▸ | MMP20 | O60882 | 1/20 | 0.30 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.30 |
| ▸ | MMP10 | P09238 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | MMP15 | P51511 | 1/20 | 0.30 |
| ▸ | MMP16 | P51512 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411900 | 0.86 | MMP3 (0.42) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL8200251 | 0.80 | KDM4C (0.33) | KDM4CKDM4APHF8KDM2AADAM17 | |
| SCHEMBL8197792 | 0.78 | MMP3 (0.38) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL7358045 | 0.76 | KDM4C (0.39) | KDM4CKDM4APHF8KDM2AMMP1 | |
| SCHEMBL8198041 | 0.76 | MMP2 (0.39) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL8534029 | 0.75 | MMP3 (0.38) | KDM4CKDM4APHF8KDM2AADAM17 | |
| SCHEMBL8198210 | 0.73 | GAA (0.39) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL7431867 | 0.73 | BMP1 (0.41) | KDM4CKDM4APHF8KDM2AMMP1 | |
| SCHEMBL7411915 | 0.71 | MMP2 (0.49) | MMP3MMP1MMP2 | |
| SCHEMBL7363096 | 0.71 | NMT2 (0.41) | KDM4CKDM4APHF8KDM2AADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | claimed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | claimed |
| US-6017889-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-01-25 | — | — | US | disclosed |
| EP-0740655-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-10-20 | — | — | EP | disclosed |
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |