Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881616 | 0.93 | LMNA (0.36) | REV1MAPTPOLBGAAHIF1A | |
| SCHEMBL8200017 | 0.92 | MAPT (0.46) | REV1MAPTPOLBGAAHIF1A | |
| SCHEMBL8211924 | 0.91 | F11 (0.36) | MAPTPOLBGAAHIF1ALMNA | |
| SCHEMBL8200330 | 0.85 | MAPT (0.45) | REV1MAPTPOLBGAAHIF1A | |
| SCHEMBL8210397 | 0.84 | KDM4E (0.41) | MAPTGAALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8212479 | 0.82 | MAPT (0.38) | MAPTPOLBGAALMNAKDM4E | |
| SCHEMBL8206343 | 0.82 | MAPT (0.47) | MAPTGAARXFP1KDM4ESMN1; SMN2 | |
| SCHEMBL8209525 | 0.78 | KMT2A (0.37) | MAPTPOLBGAANPC1RAB9A | |
| SCHEMBL8207368 | 0.77 | REV1 (0.47) | REV1MAPTPOLBGAAHIF1A | |
| SCHEMBL8200396 | 0.76 | ALDH1A1 (0.44) | MAPTPOLBGAAKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |